Polynucleotides are a type of injectable treatment that can rejuvenate the skin and improve its texture. The treatment involves injecting a clear solution of naturally occurring molecules derived from salmon DNA into the skin using a fine needle. The polynucleotides trigger a skin-repairing response that stimulates collagen and elastin production, which can help reduce the appearance of wrinkles, lines, and dark circles. The treatment can also hydrate the skin, improve its elasticity, and reduce the appearance of scars, brown spots, and stretch marks
Long strings of nucleotides, the building blocks of DNA, are called polynucleotides. They support moisturization, defense against damaging outside agents including UV radiation, and cellular regeneration.
Water molecules are drawn to and bound by the polynucleotide chains, giving rise to a potent moisturizing effect that may enhance tissue suppleness.
The ability of polynucleotides to inhibit free radicals is impressive. They play a protective and cell damage reduction role by counteracting the skin damage that can build as a result of numerous stressors, such as cellular damage, stress, and exposure to UV radiation.
The ideal environment for fibroblast growth—cells necessary for tissue regeneration and repair—is produced by polynucleotides.
Salmon is the source of polynucleotides, which can stimulate stem and fibroblast cells to increase the body’s innate ability to regenerate.
Polynucleotides are categorised as regenerative treatments due to their multifaceted functioning, which presents a novel and distinctive approach to skin care and rejuvenation.
Polynucleotides stimulate fibroblasts, which reduces fine lines and wrinkles, remodels skin texture and reduces scarring.
Skin cells are repaired to calm inflammation, such as rosacea, and promoted bi-regeneration to increase the production of collagen.
We will assess your skin concerns and goals during your consultation. We will discuss the benefits and potential risks of polynucleotide treatments and discuss other options that may be available. Your practitioner will answer any questions you have about your concerns or the treatment, and they will tailor a treatment plan to address your specific needs. They will discuss your medical history and discuss your expectations to ensure that polynucleotide injections are the right option for you. Additionally, they will also provide pre and post care advice, so you are aware of what to expect from the treatment and to optimise results and minimise any potential side effects.
Recommended
Course of 3 £1000
Polynucleotides are purified DNA fragments that stimulate your skin's own collagen and elastin production when injected. They improve skin texture, hydration, and firmness from within — without adding volume. Results develop gradually, giving a natural, healthy-looking glow over time.
Yes — polynucleotides are biocompatible and well-tolerated by most patients, with a strong clinical safety record. Mild swelling or bruising at the injection site can occur but usually clears within 48 hours. They are not suitable for those who are pregnant, breastfeeding, or allergic to fish.
Polynucleotides are regenerative skin treatments designed to support collagen production, hydration, elasticity and overall skin quality. Unlike treatments intended to alter facial movement or add volume, polynucleotides focus on improving the condition, texture and appearance of the skin itself.
The most suitable treatment will depend on your individual concerns, skin condition and desired outcome. During your consultation, your practitioner will assess your needs and explain the treatment options that may be appropriate for you.
Microneedling creates physical micro-injuries to trigger healing, making it strong for scarring and texture. Polynucleotides work biologically at a cellular level, making them ideal for overall skin quality, tone, and sensitive areas like under the eyes. Many clinics combine both in a single treatment called polyneedling for enhanced results.
For most patients, yes. Polynucleotides produce natural, long-lasting improvements to skin quality with minimal downtime and no structural change to the face. Patients seeking better texture, hydration, and glow — rather than an instant dramatic result — consistently report high satisfaction.
Results typically last between 6 and 12 months, depending on your age, skin condition, and lifestyle. The collagen stimulated by the treatment remains in your skin long after the polynucleotides are absorbed. Most practitioners recommend a maintenance session every 6 to 12 months to preserve the improvement.
Most patients need a course of 3 sessions, spaced 2 to 4 weeks apart, to see the full benefit. Results are cumulative — each session builds on the last. Some improvement in hydration and glow can be noticed after session one, but significant changes in firmness and texture typically appear after session two or three.
A single session typically costs between £200 and £500, with a full 3-session course ranging from £600 to £1,500 depending on the clinic and area treated. Many clinics offer course packages at a reduced rate. Book a consultation with us for an accurate, personalised quote.
PLEASE NOTE: Our PRP consultation fee is £50, which will be subsidized towards the cost of your treatment when you proceed with a recommended treatment plan.
If you are unable to attend your appointment, please contact us immediately on 0113 2401234 or send us an email to skin@leeds-clinic.co.uk with the subject header marked as urgent. Any cancellations must be made at least 48 hours before your appointment. Any appointment that you require to reschedule or cancel is subject to the Deposit and Cancellation Policy which can be found by clicking HERE.
Please review terms and conditions before booking Click Here To Review Terms & Conditions
